Study of the analgesic effect of the aqueous extract of the leaves of Citrus aurantifolia (Rutaceae) in mice

Citrus aurantifolia (Rutaceae) is a plant used in traditional medicine the treatment of inflammatory and analgesic pathologies. The objective this study was to evaluate activity aqueous extract leaves mice. phytochemical revealed flavonoids, tannins, polyphenols, coumarins, saponosides polyterpene sterols absence alkaloids. Concerning acute toxicity at single dose 2000 mg/ Kg pc orally, it that not toxic. Thus, according OECD guideline 423, oral LD50 range 2000-5000 mg/kg bw. orally determined by evaluating rate inhibition pain caused acetic acid. 250 bw 500 doses administered all showed activity. best obtained with an 88.64% for dose. dose, while sensation 47.57%. Therefore, has effect low doses.